Which Should You Choose: Orlistat or Xenical?
Orlistat vs Xenical: The Key Differences
When comparing how well does Alli work for weight loss against prescription options, understanding the differences between orlistat and Xenical is crucial for making an informed purchase decision. Both orlistat 120mg and Xenical 120mg contain the identical active ingredient at the same dose - orlistat. The key difference lies in cost and branding, not clinical effectiveness.
Generic orlistat 120mg costs £29.69 for a 4-week supply (with EDM10 discount), whilst branded Xenical costs £38.69 for the same period. That's a saving of £9 per month choosing generic orlistat. Both work by blocking absorption of approximately one third of dietary fat when used alongside a reduced-calorie, lower-fat diet.
How Well Does Each Option Work?
Clinically, orlistat 120mg and Xenical 120mg are equivalent - they may help support weight management to the same degree. Both inhibit lipase enzymes in the gut, reducing fat absorption by approximately one third. The unabsorbed fat passes naturally through the digestive system.
Alli 60mg contains half the dose of prescription-strength orlistat, making it a lower-strength alternative. At 60mg, Alli may help block a smaller proportion of dietary fat compared to the 120mg prescription options, but with typically milder gastrointestinal side effects.
Pricing Comparison: Save Money on Generic
Our current pricing with EDM10 discount shows significant savings choosing generic orlistat:
Orlistat 120mg: 2 weeks £15.20, 4 weeks £29.69, 8 weeks £57.59, 12 weeks £86.39
Xenical 120mg: 2 weeks £19.35, 4 weeks £38.69, 8 weeks £78.29, 12 weeks £116.09
Alli 60mg: 4 weeks £26.09, 8 weeks £49.49, 12 weeks £116.99
Over a 12-week treatment period, choosing generic orlistat saves £29.70 compared to Xenical - whilst delivering identical clinical effects.
Which Option Should You Buy?
For most patients, generic orlistat 120mg offers the best value - same clinical effect as Xenical at lower cost. Some patients prefer branded Xenical for personal preference, whilst others choose Alli 60mg as a gentler starting point. Your prescriber will assess suitability following online clinical assessment.
All three options require prescription-only assessment for 120mg products. Alli 60mg has different availability but still requires clinical review through our service. Treatment suitability depends on individual health circumstances, BMI, and medical history.
Safe, Regulated Supply from EverydayMeds
Whether you choose orlistat, Xenical, or Alli, all medication is dispensed by our GPhC-registered pharmacy in Leicester following UK prescriber review. Next-day delivery available across the UK with discreet packaging. Use code EDM10 for 10% off every order - new and returning customers welcome.


