Orlistat vs Xenical: Which Should You Choose?
Is Orlistat Any Good? The Clinical Facts
Orlistat is a prescription-only weight loss medicine that works by blocking the absorption of approximately one third of dietary fat. Both generic orlistat 120mg and branded Xenical 120mg contain the same active ingredient at identical doses, providing the same clinical effect when used alongside a reduced-calorie, lower-fat diet and increased physical activity.
Orlistat vs Xenical: Key Differences
The primary difference between orlistat and Xenical is cost. Generic orlistat 120mg costs £32.99 for 4 weeks (£29.69 with EDM10), whilst branded Xenical 120mg costs £42.99 for 4 weeks (£38.69 with EDM10). This represents savings of approximately £9 per month when choosing generic orlistat. Both are prescribed following individual clinical assessment by UK-licensed prescribers.
How Both Medicines Work
Orlistat and Xenical work identically by inhibiting lipase enzymes in the digestive system. This prevents approximately one third of dietary fat from being absorbed, with unabsorbed fat passing naturally through the body. The medicine acts locally in the gut rather than being absorbed into the bloodstream, supporting weight management when combined with dietary and lifestyle changes.
Complete Pricing Comparison
Generic Orlistat 120mg: 2 weeks £16.89 (£15.20 with EDM10), 4 weeks £32.99 (£29.69 with EDM10), 8 weeks £63.99 (£57.59 with EDM10), 12 weeks £95.99 (£86.39 with EDM10). Branded Xenical 120mg: 2 weeks £21.50 (£19.35 with EDM10), 4 weeks £42.99 (£38.69 with EDM10), 8 weeks £86.99 (£78.29 with EDM10), 12 weeks £128.99 (£116.09 with EDM10). Save 10% on every order with code EDM10.
Alli 60mg Alternative
Alli 60mg provides half the dose of prescription-strength orlistat. Available at £28.99 for 4 weeks (£26.09 with EDM10), it may be suitable for those preferring a lower-strength starting option. However, the clinical effect is proportionally reduced compared to 120mg formulations.
Online Prescription Process
Both orlistat and Xenical require prescription following clinical assessment. Complete our online health questionnaire for review by UK-licensed prescribers. If clinically appropriate, your prescription is dispensed by our GPhC-registered Leicester pharmacy with next day delivery across the UK. The prescription cost is included - no separate GP appointment needed.
Which Should You Choose?
For most patients, generic orlistat 120mg offers excellent value whilst providing identical clinical benefits to branded Xenical. Some prefer Xenical's established branding, whilst others choose orlistat for significant cost savings. Your prescriber can help determine the most suitable option during your clinical assessment. Both medicines may cause similar gastrointestinal side effects, particularly with high-fat meals.
