Ready to Start? Understanding Orlistat's Proven Mechanism
How Orlistat's Fat-Blocking Mechanism Works
Orlistat works by inhibiting lipase enzymes in your digestive system that normally break down dietary fats. When these enzymes are blocked, approximately one third of the fat you eat cannot be digested or absorbed into your body. This unabsorbed fat passes naturally through your system, effectively reducing your calorie intake from dietary fat. Unlike appetite suppressants that act on the brain, orlistat works locally in your gut and is not significantly absorbed into your bloodstream.
Why This Mechanism Matters for Weight Loss
Understanding orlistat's mechanism explains why it's effective for weight management when used alongside a reduced-calorie, lower-fat diet. By blocking approximately one third of dietary fat absorption, you're automatically reducing calories from the fat content of your meals. This makes it easier to maintain a calorie deficit needed for weight loss. The key is keeping your meals low in fat - this maximises effectiveness while minimising gastrointestinal side effects.
Can You Take Imodium With Orlistat?
Many patients ask about taking Imodium (loperamide) alongside orlistat, particularly when experiencing the medication's characteristic gastrointestinal effects. While there are no known major interactions between orlistat and Imodium, you should always consult your prescriber or pharmacist before combining any medications. The gastrointestinal effects you may experience with orlistat - such as oily stools or increased bowel frequency - are actually signs that the medication is working by preventing fat absorption.
Choosing Your Orlistat Option
We offer three orlistat options, all using the same proven fat-blocking mechanism. Generic orlistat 120mg provides the most cost-effective option at £32.99 for 4 weeks (£29.69 with EDM10). Xenical 120mg offers the same 120mg dose in branded form for £42.99 for 4 weeks (£38.69 with EDM10). Alli 60mg provides half the prescription strength at £28.99 for 4 weeks (£26.09 with EDM10). All work by the same mechanism - blocking approximately one third of dietary fat absorption.
Getting Started With Orlistat
Now that you understand how orlistat's proven mechanism works, you can make an informed decision about starting treatment. Our online consultation takes just minutes to complete, and a UK-licensed prescriber will assess your suitability based on your individual health circumstances. If prescribed, your medication is dispensed by our GPhC-registered Leicester pharmacy and delivered discreetly to your door with next-day delivery available. Use code EDM10 for 10% off every order.


