Why Understanding Orlistat's Mechanism Matters
How Orlistat Blocks Fat Absorption
Orlistat works by inhibiting lipase enzymes in your digestive system. These enzymes normally break down dietary fat so it can be absorbed into your body. When orlistat blocks these enzymes, approximately one third of the fat you eat cannot be digested or absorbed. This unabsorbed fat passes naturally through your digestive system and is eliminated from your body.
The Science Behind Fat Blocking
Unlike appetite suppressants that work in the brain, orlistat acts locally in your gut. It's not absorbed into your bloodstream in significant amounts, making its mechanism of action very targeted. This scientific approach means orlistat directly reduces the calories your body absorbs from dietary fat - approximately one third less fat absorption per meal containing fat.
Generic Orlistat vs Branded Xenical
Both generic orlistat 120mg and branded Xenical 120mg contain identical active ingredients and work through exactly the same mechanism. The clinical effect is equivalent - both block approximately one third of dietary fat absorption. The main difference is cost: generic orlistat starts from £29.69 for 4 weeks (with EDM10), while Xenical costs £38.69 for the same period. Both require prescription following clinical assessment.
Alli 60mg: Lower Strength Option
Alli contains half the dose of prescription-strength orlistat at 60mg per capsule. While it works through the same fat-blocking mechanism, it blocks a smaller proportion of dietary fat compared to the 120mg prescription versions. Alli 60mg costs £26.09 for 4 weeks with code EDM10.
What to Expect When Taking Orlistat
Because orlistat blocks approximately one third of dietary fat from being absorbed, you may experience gastrointestinal side effects, particularly if you eat high-fat meals. These effects - including oily stools, increased bowel movements, or oily spotting - are actually signs that the medication is working as intended. Keeping meals low in fat (around 15g per meal) significantly reduces these effects while maintaining the weight loss benefits.
Getting Started with Orlistat
Understanding how orlistat works shows why it's prescribed alongside a reduced-calorie, lower-fat diet. The mechanism is most effective when combined with lifestyle changes. You can start your online clinical assessment today through EverydayMeds. Our UK-licensed prescribers will review your eligibility and, if appropriate, issue a prescription for next-day delivery. Use code EDM10 for 10% off your order.
