Why Orlistat's Fat-Blocking Action Drives Results
How Orlistat's Proven Mechanism Works
Orlistat works by inhibiting lipase enzymes in your digestive system, preventing approximately one third of dietary fat from being absorbed into your body. This unabsorbed fat passes naturally through your system, reducing calorie intake from dietary fat when used alongside a reduced-calorie, lower-fat diet.
Unlike appetite suppressants that act on the brain, orlistat works locally in the gut and is not significantly absorbed into your bloodstream. This targeted action makes it a clinically proven option for weight management in adults with a BMI of 28 kg/m² or above.
Choose Your Orlistat Strength and Duration
Our GPhC-registered pharmacy offers three clinically proven options following online prescriber assessment:
Generic Orlistat 120mg (Prescription Strength): Most cost-effective option from £15.20 per fortnight. Available in 2-week (£15.20), 4-week (£29.69), 8-week (£57.59), and 12-week (£86.39) supplies with code EDM10.
Xenical 120mg (Branded): Same active ingredient as generic orlistat, manufactured by Roche. From £19.35 per fortnight, with 4-week supplies at £38.69 using EDM10 discount.
Alli 60mg: Lower-strength option at half the prescription dose. 4-week supplies from £26.09 with EDM10 code applied.
Clinical Assessment Process
All orlistat 120mg products require prescription following clinical assessment by our UK-licensed prescribers. Complete your online health questionnaire covering medical history, current medications, and BMI information. Your assessment is reviewed the same day where clinically appropriate, with medication dispensed by our Leicester-based GPhC-registered pharmacy.
Treatment may be suitable for adults with obesity (BMI 30+) or those who are overweight (BMI 28+) with weight-related health conditions such as type 2 diabetes or high blood pressure. Individual suitability depends on your specific health circumstances.
Maximising Results While Minimising Side Effects
Orlistat's fat-blocking action means gastrointestinal side effects are more likely when eating high-fat meals. Keep meals to approximately 15g fat each to optimise results while reducing the likelihood of oily stools, urgent bowel movements, or oily spotting. These effects demonstrate the medication is working by preventing fat absorption.
Take one capsule with each main meal containing fat, up to three times daily. If you miss a meal or eat a fat-free meal, skip that dose. A daily multivitamin taken at bedtime is recommended, as orlistat may reduce absorption of fat-soluble vitamins A, D, E, and K.
Start Your Weight Management Journey
Ready to access prescription-strength orlistat? Begin your online clinical assessment today. Our UK-licensed prescribers review applications the same day, with approved prescriptions dispensed immediately by our GPhC-registered pharmacy. Next day delivery available across the UK in discreet packaging. Remember to use code EDM10 for 10% off your order.


