How Does Orlistat Work for Weight Loss?
Clinical Evidence: How Orlistat Works
Orlistat works by inhibiting lipase enzymes in your digestive system, preventing approximately one third of dietary fat from being absorbed into your body. This unabsorbed fat passes naturally through your system, potentially reducing calorie intake from fat when used alongside a reduced-calorie, lower-fat diet. Unlike stimulant-based treatments, orlistat acts locally in the gut rather than affecting your brain or central nervous system.
Prescription Orlistat 120mg Options
We offer both generic orlistat 120mg and branded Xenical 120mg — both contain identical active ingredients and work in exactly the same way. Generic orlistat provides excellent value from £29.69 for 4 weeks (normally £32.99), whilst Xenical 120mg costs £38.69 for 4 weeks (normally £42.99). Both require prescription following clinical assessment by our UK-licensed prescribers.
Who May Be Suitable for Orlistat Treatment
Orlistat may be prescribed for adults with a BMI of 30 kg/m² or above, or those with a BMI of 28 kg/m² or above with weight-related health conditions such as type 2 diabetes or high blood pressure. Treatment suitability is assessed individually through our online consultation process, which replaces the need for a face-to-face GP appointment whilst maintaining the same clinical standards.
What to Expect When Taking Orlistat
Orlistat is taken as one 120mg capsule with each main meal containing fat, up to three times daily. The medication works best when combined with meals containing no more than approximately 15g of fat each. Higher fat meals may increase the likelihood of gastrointestinal side effects, which are the body's natural response to unabsorbed fat passing through the system.
Complete Treatment Packages Available
Our 8-week orlistat package costs £57.59 (normally £63.99) and includes 168 capsules plus online prescription. For longer-term treatment, our 12-week supply provides 252 capsules for £86.39 (normally £95.99). All packages include consultation, prescription, dispensing by our GPhC-registered pharmacy, and discreet next-day delivery. Use code EDM10 at checkout for automatic 10% savings.
Start Your Assessment Today
Begin your confidential online consultation now to discover whether prescription orlistat treatment may be suitable for your weight management goals. Our UK-licensed prescribers will review your health information and provide a prescription if clinically appropriate, with medication dispatched the same day from our Leicester pharmacy.


