Why Understanding Orlistat's Mechanism Matters
How Orlistat Blocks Fat Absorption
Orlistat works by inhibiting lipase enzymes in your digestive system. These enzymes normally break down dietary fat so it can be absorbed into your body. When orlistat blocks these enzymes, approximately one third of the fat you eat cannot be digested or absorbed. This unabsorbed fat passes naturally through your system and is excreted, reducing the calories your body takes in from fat.
Why Gastrointestinal Effects Occur
The oily stools, loose bowel movements, and urgent toilet visits that some people experience are actually proof that orlistat is working. The unabsorbed fat has to leave your body somehow - and this happens through your bowel movements. These effects are more noticeable when you eat high-fat meals, which is why following a lower-fat diet (approximately 15g fat per meal) significantly reduces side effects while maximising weight management benefits.
Generic Orlistat vs Xenical - Same Mechanism, Better Value
Both generic orlistat 120mg and branded Xenical 120mg contain identical active ingredients and work through exactly the same fat-blocking mechanism. The key difference is cost - generic orlistat at EverydayMeds costs £32.99 for 4 weeks (£29.69 with EDM10) compared to £42.99 for Xenical. You get the same clinical effect for approximately £10 less per month with generic orlistat.
Lower-Strength Alli 60mg Option
Alli 60mg works through the same mechanism but at half the dose of prescription-strength orlistat. While it blocks a smaller proportion of dietary fat, some people prefer starting with this lower-strength option. Alli costs £28.99 for 4 weeks at EverydayMeds (£26.09 with code EDM10).
Maximising Results While Minimising Side Effects
Understanding how orlistat works helps you use it more effectively. Keep each meal to around 15g fat or less to reduce gastrointestinal effects. The medication works best when combined with a reduced-calorie, lower-fat diet and regular physical activity. Take one capsule with each main meal containing fat - if a meal contains no fat, you can skip that dose.
Getting Started with EverydayMeds
Our GPhC-registered pharmacy makes accessing orlistat simple. Complete an online clinical assessment, have your information reviewed by a UK-licensed prescriber, and receive your medication with next-day delivery. Starting packs of 42 capsules (2 weeks) cost just £16.89, or £15.20 with code EDM10. All prices include the prescription - no separate GP visit required.
