Why Orlistat's Fat-Blocking Mechanism Works
How Orlistat Blocks Fat Absorption
Orlistat works through a targeted mechanism that inhibits lipase enzymes in your digestive system. These enzymes normally break down dietary fat so it can be absorbed into your body. When orlistat blocks these lipases, approximately one third of the fat you eat cannot be digested or absorbed. This unabsorbed fat passes naturally through your system, reducing the calories your body takes in from dietary fat. This mechanism makes orlistat fundamentally different from appetite suppressants - it works locally in your gut rather than affecting your brain or metabolism.
Alli vs Orlistat vs Xenical: Same Mechanism, Different Strengths
All three products use identical fat-blocking technology. Alli 60mg provides a lower-strength option at £26.09 for 4 weeks with EDM10, whilst prescription-strength orlistat 120mg costs £29.69 for 4 weeks with EDM10. Xenical 120mg, the branded version, costs £38.69 for 4 weeks with EDM10. The higher 120mg dose blocks a greater proportion of dietary fat but requires clinical assessment by our UK-licensed prescribers. Understanding this mechanism helps explain why keeping meals low in fat reduces side effects - less unabsorbed fat means fewer gastrointestinal effects.
Why This Mechanism Supports Weight Management
The fat-blocking mechanism works because fat contains 9 calories per gram - more than double that of carbohydrates or protein. By preventing approximately one third of dietary fat absorption, orlistat can significantly reduce calorie intake when used alongside a reduced-calorie, lower-fat diet. Clinical studies show this mechanism can support meaningful weight loss when combined with lifestyle changes. The key is consistency - taking orlistat with each main meal containing fat ensures the lipase-blocking effect works throughout your eating pattern.
Order Today: Choose Your Orlistat Strength
Now you understand how orlistat's proven fat-blocking mechanism works, you can choose the right strength for your needs. Start with generic orlistat 120mg at £57.59 for 8 weeks with EDM10, or try Alli 60mg at £49.49 for 8 weeks with EDM10. All options include online clinical assessment by UK-licensed prescribers, dispensing by our GPhC-registered Leicester pharmacy, and next-day delivery. Use code EDM10 for 10% off every order. Complete your assessment today and start your weight management journey with proven fat-blocking technology.


