Cold Sore Treatments: Your Essential Checklist

Cold sores affect up to 70% of UK adults, causing painful blisters around the lips and mouth. Effective treatment can significantly reduce symptoms and healing time when started early. This comprehensive checklist covers prescription antivirals like aciclovir, topical treatments, and essential self-care measures. Understanding your treatment options helps you manage outbreaks more effectively and may reduce their frequency and severity over time.

  • Start antiviral treatment within 72 hours of first symptoms for best results
  • Aciclovir tablets (400mg) are the most commonly prescribed oral treatment
  • Topical aciclovir cream can be applied directly to affected areas
  • Avoid touching cold sores and wash hands frequently to prevent spreading
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Available Treatments

Choose from a wide range of clinically-proven, safe, and effective treatments for Cold Sore.

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Aciclovir Tablets

From £12.99

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Aciclovir 5% Cream

From £8.99

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Valaciclovir

From £18.99

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Valtrex

From £34.99

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Prescription Antiviral Treatments for Cold Sores

Primary Antiviral Medications

Aciclovir tablets remain the gold standard treatment for cold sores in the UK. The typical prescription dose is 400mg taken five times daily for five days, though treatment should ideally begin within 72 hours of symptom onset for maximum effectiveness. EverydayMeds stocks aciclovir 400mg tablets, providing convenient access to this essential antiviral medication.

Alternative Prescription Options

Valaciclovir tablets offer another effective treatment option, often requiring less frequent dosing than aciclovir. Available as valaciclovir 500mg tablets or the branded Valtrex, this medication converts to aciclovir in the body but may achieve higher blood levels. Your prescriber can determine which antiviral medication best suits your individual needs and outbreak pattern.

Topical Treatment Applications

Aciclovir 5% cream provides localised treatment when applied directly to cold sores. This topical approach can be particularly useful for those who prefer external application or experience side effects from oral medications. The cream should be applied five times daily to the affected area, starting as soon as tingling or early symptoms appear.

Treatment Timing and Effectiveness

Early intervention significantly impacts treatment success. The prodromal stage - characterised by tingling, burning, or itching sensations - represents the optimal treatment window. Starting antiviral therapy during this phase may prevent blister formation entirely or substantially reduce outbreak severity and duration.

Managing Recurrent Outbreaks

For individuals experiencing frequent cold sore episodes (more than six per year), suppressive therapy may be considered. This involves taking daily antiviral medication to reduce outbreak frequency and severity. Your healthcare provider can assess whether suppressive treatment would be appropriate based on your outbreak history and individual circumstances.

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Once you complete a short online assessment, you’ll be able to choose your preferred treatment and quantity from a list of safe, medically approved options tailored to you.

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