Managing Cold Sore Treatment Side Effects

Cold sore medications like aciclovir can cause side effects ranging from mild nausea to skin irritation. Understanding these effects helps you manage treatment more effectively. Most side effects are temporary and manageable with proper care. This guide covers common reactions to cold sore tablets and creams, when to seek medical advice, and practical tips for minimising discomfort during your treatment journey.

  • Recognise common side effects like headaches, nausea and dizziness
  • Monitor for serious reactions requiring immediate medical attention
  • Apply practical strategies to reduce treatment-related discomfort
  • Know when to contact your GP or pharmacist for guidance
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Available Treatments

Choose from a wide range of clinically-proven, safe, and effective treatments for Cold Sore.

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Aciclovir Tablets

From £12.99

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Aciclovir 5% Cream

From £8.99

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Valaciclovir

From £18.99

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Valtrex

From £34.99

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Common Side Effects of Cold Sore Medications

Understanding Aciclovir Side Effects

Aciclovir tablets, the most commonly prescribed cold sore treatment, can cause several side effects. Most people experience mild reactions, with nausea affecting approximately 5-10% of users. Headaches and dizziness may also occur, particularly when starting treatment. These effects typically diminish as your body adjusts to the medication.

Topical Treatment Reactions

Cold sore creams containing aciclovir may cause localised skin reactions. Mild stinging, burning or redness at the application site affects some users initially. Contact dermatitis, though uncommon, can develop in sensitive individuals. If irritation persists beyond the first few applications, discontinue use and consult your pharmacist.

Managing Treatment Side Effects

Take aciclovir tablets with food to reduce stomach upset and nausea. Stay well-hydrated throughout treatment to minimise kidney-related effects. For topical treatments, apply thin layers and avoid excessive rubbing. If experiencing dizziness, avoid driving until symptoms settle. Most side effects resolve within 2-3 days of continued use.

When to Seek Medical Advice

Contact your GP immediately if you experience severe allergic reactions, including facial swelling, difficulty breathing or widespread rash. Unusual bruising, extreme fatigue or yellowing of skin/eyes may indicate serious complications. EverydayMeds stocks various cold sore treatments including aciclovir tablets and valaciclovir, with pharmacist support available for side effect management.

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