Common Side Effects of Cold Sore Medications
Understanding Aciclovir Side Effects
Aciclovir tablets, the most commonly prescribed cold sore treatment, can cause several side effects. Most people experience mild reactions, with nausea affecting approximately 5-10% of users. Headaches and dizziness may also occur, particularly when starting treatment. These effects typically diminish as your body adjusts to the medication.
Topical Treatment Reactions
Cold sore creams containing aciclovir may cause localised skin reactions. Mild stinging, burning or redness at the application site affects some users initially. Contact dermatitis, though uncommon, can develop in sensitive individuals. If irritation persists beyond the first few applications, discontinue use and consult your pharmacist.
Managing Treatment Side Effects
Take aciclovir tablets with food to reduce stomach upset and nausea. Stay well-hydrated throughout treatment to minimise kidney-related effects. For topical treatments, apply thin layers and avoid excessive rubbing. If experiencing dizziness, avoid driving until symptoms settle. Most side effects resolve within 2-3 days of continued use.
When to Seek Medical Advice
Contact your GP immediately if you experience severe allergic reactions, including facial swelling, difficulty breathing or widespread rash. Unusual bruising, extreme fatigue or yellowing of skin/eyes may indicate serious complications. EverydayMeds stocks various cold sore treatments including aciclovir tablets and valaciclovir, with pharmacist support available for side effect management.






