What Causes Cold Sores and Fever Blisters?

Cold sores and fever blisters are caused by the herpes simplex virus type 1 (HSV-1), which affects up to 70% of the UK population. Understanding outbreak triggers helps you manage symptoms effectively. Once infected, the virus remains dormant and can reactivate during times of stress, illness, or weakened immunity. Early recognition of triggers and prompt treatment with antivirals like aciclovir can significantly reduce outbreak severity and duration.

  • Herpes simplex virus type 1 (HSV-1) primary infection
  • Stress, fatigue, and weakened immune system
  • Sun exposure and extreme weather conditions
  • Hormonal changes during menstruation or pregnancy
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Available Treatments

Choose from a wide range of clinically-proven, safe, and effective treatments for Cold Sore.

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Aciclovir Tablets

From £12.99

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Aciclovir 5% Cream

From £8.99

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Valaciclovir

From £18.99

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Valtrex

From £34.99

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Understanding Cold Sore Triggers and Outbreak Management

Primary HSV-1 Infection

Cold sores are primarily caused by herpes simplex virus type 1 (HSV-1). Initial infection often occurs during childhood through direct contact with infected saliva, sharing utensils, or kissing. Many people experience no symptoms during first infection, whilst others may develop painful blisters around the mouth. Once contracted, HSV-1 remains dormant in nerve cells and can reactivate throughout life.

Common Outbreak Triggers

Several factors can trigger cold sore outbreaks in those carrying HSV-1. Stress and fatigue significantly weaken the immune system, making reactivation more likely. Sun exposure, particularly UV radiation, commonly triggers outbreaks - many people notice cold sores appearing after holidays or outdoor activities. Hormonal fluctuations during menstruation, pregnancy, or menopause can also precipitate episodes.

Lifestyle and Environmental Factors

Illness, particularly fever or upper respiratory infections, frequently triggers outbreaks - hence the term "fever blisters". Extreme weather conditions, both hot and cold, can stress the skin and immune system. Dental procedures or lip injuries may also activate dormant virus. Poor nutrition, lack of sleep, and excessive alcohol consumption can compromise immunity and increase outbreak frequency.

Effective Outbreak Management

Recognising early warning signs allows prompt treatment initiation. The characteristic tingling, burning, or itching sensation typically precedes visible blisters by 12-24 hours. Starting antiviral treatment like aciclovir tablets during this prodromal phase may prevent blister formation entirely. EverydayMeds offers aciclovir 400mg tablets and topical treatments that can reduce outbreak duration when used appropriately. Maintaining good general health, managing stress levels, and using sun protection may help reduce outbreak frequency over time.

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