What Causes Cold Sores and Fever Blisters?

Cold sores and fever blisters are common viral infections affecting up to 70% of the UK population. These painful blisters, caused by herpes simplex virus type 1 (HSV-1), typically appear around the lips and mouth. Understanding their causes, triggers, and what to expect during an outbreak can help you manage symptoms effectively. Early treatment with antiviral medications like aciclovir may reduce severity and duration.

  • Initial infection occurs through direct contact with infected person
  • Stress, illness, and sun exposure commonly trigger recurrent outbreaks
  • Symptoms progress through five distinct stages over 7-10 days
  • Antiviral treatments work best when started at first tingling sensation
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Available Treatments

Choose from a wide range of clinically-proven, safe, and effective treatments for Cold Sore.

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Aciclovir Tablets

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Aciclovir 5% Cream

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Valaciclovir

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Valtrex

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Understanding Cold Sore Development and Treatment

Primary Causes of Cold Sores

Cold sores result from infection with herpes simplex virus type 1 (HSV-1), though HSV-2 may occasionally cause oral lesions. The initial infection typically occurs during childhood through close contact with an infected person, often through kissing or sharing utensils. Many people contract the virus without developing visible symptoms, whilst others experience their first outbreak within days of exposure.

Common Outbreak Triggers

Once infected, the virus remains dormant in nerve cells and may reactivate periodically. Common triggers include physical or emotional stress, illness or fever, hormonal changes during menstruation, sun or wind exposure, and immune system suppression. Some individuals experience frequent outbreaks, whilst others may never develop symptoms despite carrying the virus.

What to Expect During an Outbreak

Cold sore development follows predictable stages. The prodromal stage begins with tingling, burning, or itching sensations around the affected area, typically lasting 12-24 hours. The vesicular stage sees small, fluid-filled blisters forming in clusters, usually within 24-48 hours of initial symptoms. During the ulcerative stage, blisters burst and form shallow, painful ulcers - this is when you're most contagious. The crusting stage involves scab formation over 2-3 days, followed by the healing stage where scabs fall off naturally, revealing new skin underneath.

Available Treatment Options

Antiviral medications like aciclovir tablets can significantly reduce outbreak severity and duration when started early. Aciclovir 400mg tablets, available through EverydayMeds, work by preventing viral replication, potentially shortening healing time by 1-2 days. Topical treatments such as aciclovir 5% cream may provide localised relief for mild outbreaks. Alternative antiviral options include valaciclovir tablets, which require less frequent dosing than aciclovir.

Prevention and Management Strategies

Avoiding known triggers can help reduce outbreak frequency. This includes managing stress levels, using lip balm with SPF protection, maintaining good hygiene, and avoiding sharing personal items. During active outbreaks, avoid kissing and close contact to prevent transmission. Keeping the affected area clean and dry supports natural healing processes.

When to Seek Treatment

Consider antiviral treatment if you experience frequent outbreaks, severe symptoms, or complications such as bacterial infection. Immunocompromised individuals should seek prompt medical attention for any cold sore symptoms. Early intervention with prescription antivirals from EverydayMeds may help minimise outbreak impact and reduce transmission risk to others.

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