Why Choose Prescription Weight Loss Treatment?
Orlistat and Metformin Together for Weight Management
Many patients ask about using orlistat alongside metformin for weight management. Metformin is commonly prescribed for type 2 diabetes and may have weight management benefits, while orlistat is a dedicated prescription weight loss medication. When used together under medical supervision, these treatments may complement each other as part of a comprehensive weight management programme.
Orlistat works by blocking approximately one third of dietary fat absorption in the gut, helping to reduce calorie intake from fat. This mechanism is different from metformin, which primarily helps control blood sugar levels. For patients with type 2 diabetes and a BMI of 28 kg/m² or above, this combination may be particularly relevant following clinical assessment.
Prescription Orlistat Options Available
We offer three orlistat options to suit different needs and budgets. Generic orlistat 120mg provides the most cost-effective choice at £15.20 for a 2-week supply (with EDM10). Branded Xenical 120mg contains the identical active ingredient at £19.35 for 2 weeks. For those preferring a lower-strength option, Alli 60mg is available from £26.09 for a 4-week supply.
All 120mg products require a prescription following clinical assessment. Our UK-licensed prescribers will review your medical history, current medications including metformin, and weight management goals to determine the most suitable treatment approach.
Clinical Assessment Process
The online consultation process is designed to be thorough yet convenient. You'll complete a detailed health questionnaire covering your medical history, current medications, BMI, and weight management objectives. This information is reviewed by a qualified UK-licensed prescriber who will assess whether orlistat treatment is clinically appropriate for your individual circumstances.
If you're currently taking metformin, this will be considered as part of the assessment. The prescriber will ensure there are no contraindications and that the combination of treatments is suitable for your health profile. Treatment can typically be prescribed within 24 hours of completing the consultation.
Pricing and Pack Sizes
Generic orlistat 120mg offers excellent value: 4-week supply £29.69, 8-week supply £57.59, or 12-week supply £86.39 (all prices with EDM10 discount). Branded Xenical costs slightly more but contains the identical active ingredient: 4-week supply £38.69, 8-week supply £78.29, or 12-week supply £116.09 with EDM10.
Alli 60mg provides a lower-strength alternative: 8-week supply £49.49 or 12-week supply £116.99 with EDM10. All customers receive 10% off every order with code EDM10, whether new or returning patients.
How Orlistat Supports Weight Management
Orlistat is a lipase inhibitor that works locally in the digestive system. It blocks approximately one third of dietary fat from being absorbed, with unabsorbed fat passing naturally through the body. This mechanism helps reduce calorie intake from dietary fat when used alongside a reduced-calorie, lower-fat diet and increased physical activity.
The medication works best when fat intake is kept to approximately 15g per meal. Higher fat meals increase the likelihood of gastrointestinal side effects, which are manageable by following dietary guidance. Most patients find side effects reduce over time as they adapt to a lower-fat eating pattern.
Delivery and Next Steps
All medication is dispensed by our GPhC-registered pharmacy in Leicester and delivered discreetly to your address. Next day delivery is available across the UK with tracking provided. The prescription is included in the price - no separate GP fees apply.
Ready to start your weight management journey? Complete the online consultation today to speak with a UK-licensed prescriber about orlistat treatment. With prices from £15.20 and 10% off every order, professional weight loss support has never been more accessible.


