Orlistat vs Xenical: Which Should You Choose?
Orlistat 120mg vs Xenical 120mg: The Key Facts
Both orlistat 120mg and Xenical 120mg contain the same active ingredient at identical doses. The clinical effect is equivalent—both work by blocking approximately one third of dietary fat absorption in the gut. The primary difference lies in cost and branding. Generic orlistat provides the same weight management support at a significantly lower price point, making it the preferred choice for cost-conscious patients.
Price Comparison: Orlistat vs Xenical
Generic orlistat offers substantial savings compared to branded Xenical. For a 4-week supply (84 capsules), orlistat costs £32.99 (£29.69 with EDM10) whilst Xenical costs £42.99 (£38.69 with EDM10). Over 12 weeks, you could save approximately £30 by choosing generic orlistat at £95.99 versus Xenical at £128.99. Both require the same online clinical assessment and are dispensed by our GPhC-registered pharmacy.
Clinical Effectiveness: Are They Really the Same?
Yes—orlistat 120mg and Xenical 120mg are clinically equivalent. Both inhibit lipase enzymes in the digestive system, preventing approximately one third of dietary fat from being absorbed. The unabsorbed fat passes naturally through the body. Response rates, side effect profiles, and mechanism of action are identical. Your choice between generic and branded comes down to personal preference and budget considerations.
What About Alli 60mg?
Alli 60mg offers half the dose of prescription-strength orlistat. At £28.99 for 4 weeks (£26.09 with EDM10), it provides a lower-strength alternative for those preferring a gentler starting point. However, the reduced dose means less dietary fat is blocked compared to the 120mg prescription options. Alli may be suitable for some patients, but many find the 120mg prescription strength more effective for weight management goals.
Online Prescription Process
Both orlistat and Xenical require prescription following clinical assessment. Complete our online health questionnaire covering medical history, current medications, and BMI information. A UK-licensed prescriber reviews your application and issues a prescription where clinically appropriate. The process typically takes 24 hours, with next day delivery available across the UK. Your prescription is included in the price—no separate GP appointment needed.
Choosing Your Treatment
Consider generic orlistat 120mg if cost is a priority—you'll receive identical clinical benefits at lower cost. Choose Xenical 120mg if you prefer branded medication from Roche. Both work alongside a reduced-calorie, lower-fat diet and are suitable for adults with BMI 30+ or BMI 28+ with weight-related health conditions. Side effects are identical and primarily gastrointestinal, minimised by keeping dietary fat intake low.
Start Your Clinical Assessment Today
Ready to begin your weight management journey? Choose between orlistat 120mg or Xenical 120mg and complete your online consultation. Both are available with 10% discount using code EDM10. Our UK-licensed prescribers will assess your suitability and arrange discreet delivery to your address. Treatment may help support weight loss when used alongside appropriate dietary and lifestyle changes.


