The Science Behind Orlistat - Why It Works
How Orlistat Blocks Fat Absorption
Orlistat works by inhibiting lipase enzymes in your digestive system. These enzymes are responsible for breaking down dietary fat so it can be absorbed into your body. When orlistat blocks these enzymes, approximately one third of the fat you eat cannot be digested or absorbed. This unabsorbed fat passes naturally through your digestive system and is eliminated from your body.
Unlike appetite suppressants that work in the brain, orlistat acts locally in your gut and is not significantly absorbed into your bloodstream. This targeted mechanism makes it a clinically proven approach to reducing calorie intake from dietary fat.
Three Orlistat Options Available
Generic orlistat 120mg offers the most cost-effective option at £32.99 for 4 weeks (£29.69 with EDM10). Branded Xenical 120mg contains the same active ingredient at £42.99 for 4 weeks (£38.69 with EDM10). Both require a prescription following clinical assessment by our UK-licensed prescribers.
Alli 60mg provides a lower-strength option at £28.99 for 4 weeks (£26.09 with EDM10). While containing half the dose of prescription strength, Alli still works by the same fat-blocking mechanism.
What Happens When You Take Orlistat
When you take orlistat with a meal containing fat, the medication begins working immediately in your digestive system. The lipase enzymes that would normally break down fat are inhibited, preventing approximately one third of dietary fat from being processed and absorbed.
The remaining two thirds of fat is still digested normally, which is why orlistat must be used alongside a reduced-calorie, lower-fat diet for optimal results. The lower your fat intake per meal, the fewer gastrointestinal side effects you may experience.
Clinical Evidence for Fat Blocking
The "approximately one third" figure comes from extensive clinical studies showing orlistat blocks around 30% of dietary fat absorption. This consistent, measurable effect has made orlistat a trusted prescription weight management option across the UK and worldwide.
The mechanism is dose-dependent - orlistat 120mg blocks more fat than Alli 60mg, which explains why the prescription strength requires clinical assessment and monitoring by qualified healthcare professionals.
Order Your Orlistat Today
Now you understand how orlistat's fat-blocking mechanism works, you can make an informed choice about your weight management. Complete our online clinical assessment for prescription orlistat 120mg or Xenical, or order Alli 60mg directly. Use code EDM10 for 10% off every order with next day delivery from our GPhC-registered Leicester pharmacy.
