Aciclovir Side Effects: Headaches & What to Expect

Aciclovir is an effective antiviral medication for treating cold sores, but like all medicines, it can cause side effects. Headaches are among the most commonly reported side effects of aciclovir treatment. Understanding these potential effects helps you make informed decisions about your cold sore treatment and know when to seek medical advice for optimal management.

  • Headaches occur in approximately 1 in 10 people taking aciclovir tablets
  • Most side effects are mild and resolve without requiring treatment discontinuation
  • Drinking plenty of water may help reduce headache frequency during treatment
  • Serious side effects are rare but require immediate medical attention
Start your free consultation

Takes less than 2 minutes to complete, 100% online

usp of our everydaymeds for Cold Sore
usp of our everydaymeds for Cold Sore

Available Treatments

Choose from a wide range of clinically-proven, safe, and effective treatments for Cold Sore.

Frame 1321316359 (10).jpg__PID:683ae17e-3507-4d0b-af25-8c85abe00602

Aciclovir Tablets

From £12.99

Learn More
Frame 1321316360 (7).png__PID:dff4fe28-0ac9-428c-81e8-588045465bec

Aciclovir 5% Cream

From £8.99

Learn More
Frame 1321316361 (9).png__PID:a273f1c4-f302-426c-a281-03d0042e6c32

Valaciclovir

From £18.99

Learn More
Frame 1321316362 (7).png__PID:6fbcd9fa-032a-4beb-9e7c-b485a775f164

Valtrex

From £34.99

Learn More

Understanding Aciclovir Side Effects and Management

Common Side Effects of Aciclovir

Aciclovir tablets are generally well-tolerated, but some people may experience side effects during treatment. The most frequently reported side effects include headaches, which affect approximately 1 in 10 people taking the medication. Other common side effects include nausea, vomiting, diarrhea, and stomach pain. These effects are typically mild and often resolve as your body adjusts to the medication.

Why Headaches Occur with Aciclovir

Headaches during aciclovir treatment may occur due to several factors. The medication can occasionally affect the central nervous system, leading to headache symptoms. Dehydration might also contribute to headaches, as aciclovir can sometimes cause nausea which may reduce fluid intake. Additionally, the stress of managing a cold sore outbreak itself can trigger tension headaches in some individuals.

Managing Aciclovir-Related Headaches

If you experience headaches while taking aciclovir, several strategies may help alleviate discomfort. Staying well-hydrated by drinking plenty of water throughout your treatment course is important. Taking your medication with food may help reduce stomach-related side effects that could contribute to headaches. Over-the-counter pain relievers like paracetamol or ibuprofen can usually be taken alongside aciclovir, but always check with your pharmacist first.

When to Seek Medical Advice

While mild headaches are relatively common, certain symptoms warrant immediate medical attention. Severe headaches, particularly those accompanied by confusion, vision changes, or neck stiffness, require urgent evaluation. Similarly, signs of allergic reactions such as rash, swelling, or breathing difficulties need immediate medical care. Contact your healthcare provider if side effects become severe or interfere with daily activities.

Aciclovir Treatment Options at EverydayMeds

EverydayMeds offers several aciclovir formulations for cold sore treatment, including Aciclovir 400mg tablets and Aciclovir 5% cream. The oral tablets are typically prescribed for more severe or frequent outbreaks, while the topical cream may be suitable for mild symptoms. Alternative antiviral options like Valaciclovir 500mg tablets are also available for those who may not tolerate aciclovir well. Our online consultation service helps determine the most appropriate treatment option based on your individual circumstances and medical history.

How it
Works?

Group 469326.png__PID:d1d71928-56cc-4f79-bdc7-0a45d0bc6b99
Background (1).png__PID:62282697-4455-4e74-a869-705c14f98b30
Background (3).png__PID:72aeaaf6-bb5b-4dd5-8914-6efdf80a1555

Start your assessment
for Cold Sore

Start your journey to better health today.

List.svg__PID:b4a5b990-cf62-48e4-ba8f-0a8bffce6cc6

Start your journey to better health today.

Once you complete a short online assessment, you’ll be able to choose your preferred treatment and quantity from a list of safe, medically approved options tailored to you.

Start My Assessment

Returning customer?

Log in to Your Account

Frequently asked questions