{"product_id":"spedra-50mg-tablets","title":"Spedra Tablets","description":"\u003ch2\u003eAbout Spedra Tablets (50 mg, 100 mg, 200 mg)\u003c\/h2\u003e\n\u003cp\u003eSpedra contains \u003cstrong\u003eavanafil\u003c\/strong\u003e, a fast-acting prescription medicine for the treatment of erectile dysfunction (ED) in adult men. ED is the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance. Spedra is licensed in the UK and regulated by the MHRA. It works by enhancing the natural erectile response to sexual stimulation, allowing improved blood flow to the penis.\u003c\/p\u003e\n\n\u003ch3\u003ePharmacology and Mechanism of Action\u003c\/h3\u003e\n\u003cp\u003eAvanafil is a selective phosphodiesterase type-5 (PDE5) inhibitor. During sexual arousal, nitric oxide (NO) release activates guanylate cyclase, increasing cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. PDE5 breaks down cGMP; avanafil inhibits PDE5, sustaining cGMP levels, relaxing smooth muscle, and increasing penile blood flow.\u003c\/p\u003e\n\n\u003ch3\u003eWhy Spedra?\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003eFast onset:\u003c\/strong\u003e Clinical effect may begin within 15–30 minutes for many men (some as early as 15 minutes).\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eShorter half-life:\u003c\/strong\u003e Effective for around 4–6 hours, allowing a flexible dosing window.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003eWell tolerated:\u003c\/strong\u003e Designed to reduce the likelihood of visual side effects compared to older PDE5 inhibitors.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eDose Selection\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003e\n\u003cstrong\u003e50 mg:\u003c\/strong\u003e Recommended starting dose for men on certain interacting medicines or with increased sensitivity to PDE5 inhibitors.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e100 mg:\u003c\/strong\u003e Standard starting dose for most men with ED; balances efficacy and tolerability.\u003c\/li\u003e\n  \u003cli\u003e\n\u003cstrong\u003e200 mg:\u003c\/strong\u003e For those who have tried 100 mg without adequate effect and have tolerated it well. Use only on medical advice.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eOnset and Duration\u003c\/h3\u003e\n\u003cul\u003e\n  \u003cli\u003eOnset: ~15–30 minutes after dosing.\u003c\/li\u003e\n  \u003cli\u003eDuration: 4–6 hours.\u003c\/li\u003e\n  \u003cli\u003eFood: High-fat meals can delay absorption and onset — for best effect, take on an empty stomach.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eWho Can Use Spedra?\u003c\/h3\u003e\n\u003cp\u003eSuitable for adult men with diagnosed ED following a UK prescriber assessment. Not for women or under-18s. A prescriber will consider cardiovascular health, potential drug interactions, and underlying causes before prescribing.\u003c\/p\u003e","brand":"Spedra®","offers":[{"title":"50mg \/ 4 Tablets","offer_id":55854914634073,"sku":"EDM-384","price":22.99,"currency_code":"GBP","in_stock":true},{"title":"50mg \/ 8 Tablets","offer_id":55854914666841,"sku":"EDM-385","price":47.99,"currency_code":"GBP","in_stock":true},{"title":"50mg \/ 12 Tablets","offer_id":55854914699609,"sku":"EDM-386","price":62.99,"currency_code":"GBP","in_stock":true},{"title":"50mg \/ 16 Tablets","offer_id":55854914732377,"sku":"EDM-387","price":82.99,"currency_code":"GBP","in_stock":true},{"title":"50mg \/ 24 Tablets","offer_id":55854914765145,"sku":"EDM-388","price":124.99,"currency_code":"GBP","in_stock":true},{"title":"50mg \/ 32 Tablets","offer_id":55854914797913,"sku":"EDM-389","price":164.99,"currency_code":"GBP","in_stock":true},{"title":"100mg \/ 4 Tablets","offer_id":58658949300569,"sku":"EDM-390","price":26.99,"currency_code":"GBP","in_stock":true},{"title":"100mg \/ 8 Tablets","offer_id":58658949333337,"sku":"EDM-391","price":52.99,"currency_code":"GBP","in_stock":true},{"title":"100mg \/ 12 Tablets","offer_id":58658949366105,"sku":"EDM-392","price":76.99,"currency_code":"GBP","in_stock":true},{"title":"100mg \/ 16 Tablets","offer_id":58658949398873,"sku":"EDM-393","price":96.99,"currency_code":"GBP","in_stock":true},{"title":"100mg \/ 24 Tablets","offer_id":58658949431641,"sku":"EDM-394","price":146.99,"currency_code":"GBP","in_stock":true},{"title":"100mg \/ 32 Tablets","offer_id":58658949464409,"sku":"EDM-395","price":196.99,"currency_code":"GBP","in_stock":true},{"title":"200mg \/ 4 Tablets","offer_id":58658949497177,"sku":"EDM-396","price":32.99,"currency_code":"GBP","in_stock":true},{"title":"200mg \/ 8 Tablets","offer_id":58658949529945,"sku":"EDM-397","price":66.99,"currency_code":"GBP","in_stock":true},{"title":"200mg \/ 12 Tablets","offer_id":58658949562713,"sku":"EDM-398","price":99.99,"currency_code":"GBP","in_stock":true},{"title":"200mg \/ 16 Tablets","offer_id":58658949595481,"sku":"EDM-399","price":129.99,"currency_code":"GBP","in_stock":true},{"title":"200mg \/ 24 Tablets","offer_id":58658949628249,"sku":"EDM-400","price":189.99,"currency_code":"GBP","in_stock":true},{"title":"200mg \/ 32 Tablets","offer_id":58658949661017,"sku":"EDM-401","price":249.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0935\/0479\/9065\/files\/Frame1321317102.png?v=1784898473","url":"https:\/\/everydaymeds.co.uk\/products\/spedra-50mg-tablets","provider":"EveryDayMeds","version":"1.0","type":"link"}